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The post lists uncontrolled hypertension, baseline tachycardia, coronary artery disease, a history of arrhythmia, thyroid cancer or medullary thyroid carcinoma, glaucoma, and concurrent stimulant use

The mechanism of action by which GLP-1 RAs work is to stimulate insulin release, inhibit glucagon release, and slow gastric emptying to slow glucose absorption [42]

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For individuals at moderate risk of gastrointestinal complications, combined therapy of NSAIDs with a gastroprotective agent should be considered

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For most users these effects subside as the skin adapts, but a meaningful minority cannot tolerate tretinoin at full strength, and it is generally contraindicated in pregnancy and while breastfeeding